Extrapersonal space can be defined by coordinate systems, or frames of reference, that are centred on the body (viewer) or on the environment. Although these frames are identical in the upright position, when the body is placed in positions orthogonal to gravity, the frames may be dissociable. We compared the influences of environmental and body-centred frames on line bisection in two patients with neglect who, when upright, neglected opposite dimensions of space.Through certain combinations of line placement and body orientation, the body and environmental frames were brought into opposition, and each frame predicted line bisection errors in an opposite direction. When the patients were positioned so that predictions of the two frames contrasted, both bisected lines as predicted by the environmental rather than the body-centred frame. © 1994 Oxford University Press.