Establishing a targeted plan for prophylactic dental extractions in patients with laryngeal cancer receiving adjuvant radiotherapy

Academic Article


  • Objective The purpose of this study was to determine dose delivered to individual mandibular tooth-bearing regions during adjuvant intensity-modulated radiotherapy for laryngeal cancers. Study Design Twenty patients with laryngeal cancer treated with intensity-modulated radiotherapy were included. Individual mandibular tooth-borne areas were manually contoured. Average doses were calculated for individual teeth. Results Doses to individual teeth increased with more posterior location. Highest dose was observed for third molar (M3) (43.1 Gy; P <.001). Doses to molars and premolars correlated with T- and N-stage (P =.007; P <.001, respectively). For ipsilateral nodal disease, there was no difference between the doses to ipsilateral teeth and contralateral teeth. Only in N2 c tumors, dose was above our threshold for extraction for M3 only (51.5 Gy). Conclusions T- and N-stage drive dose to individual mandibular tooth-borne areas. With the exception of the posterior molars, particularly in node-positive patients, radiation exposure falls below the threshold reported for pre-RT tooth extractions (50 Gy). We concluded that a more conservative approach to prophylactic tooth extraction with a greater emphasis on dental management may be warranted for the prevention of osteoradionecrosis in patients with laryngeal cancer receiving adjuvant RT.
  • Digital Object Identifier (doi)

    Author List

  • Hentz C; Diaz AZ; Borrowdale RW; Emami B; Kase M; Choi M
  • Start Page

  • 43
  • End Page

  • 49
  • Volume

  • 122
  • Issue

  • 1