A Mixed-Methods Study Examining Adherence to and Acceptability of Intravaginal Rings for HIV Prevention: Behavioral Results of MTN-027

Academic Article


  • Intravaginal rings (IVR) containing antiretroviral drugs are a promising method for HIV prevention. We triangulated quantitative and qualitative assessments to evaluate the acceptability of four IVRs used continuously for 28 days as part of a Phase I trial (N = 48 HIV-negative women; ages 18–45). Adherence was high throughout the trial, yet 30% of participants reported involuntary IVR expulsions followed by re-insertion. Most participants (93.6%) felt comfortable with the IVR being inside their body. Participants reported liking the IVR more (36.2%) or the same amount (55.3%) since starting the study. When given the option of choosing between the IVR and/or a male condom for HIV-prevention, most reported preferring the IVR (n = 29, 63.0%), and over a quarter of the sample reported liking them equally (n = 12, 26.1%). We observed no differences in IVR acceptability across the study arms. High adherence and acceptability underscores the promise of an IVR as a female-controlled, sustained mechanism for HIV prevention.
  • Authors

    Published In

  • AIDS and Behavior  Journal
  • Digital Object Identifier (doi)

    Author List

  • Bauermeister JA; Golinkoff JM; Carballo-Diéguez A; Giguere R; López D; Hoesley CJ; Chen BA; Anderson P; Dezzutti CS; Strizki J
  • Start Page

  • 607
  • End Page

  • 616
  • Volume

  • 24
  • Issue

  • 2