© 2018 Elsevier Inc. All rights reserved. Stroke or cerebrovascular accident is an acute disease of blood vessels of the brain. The most common form, ischemic stroke, results in death of brain tissue from lack of oxygen and nutrients when a blood vessel is blocked by a disease process including clot, or arteriosclerosis. Less common is death of brain tissue due to bleeding from a ruptured vessel, hemorrhagic stroke. In 2014, the fifth leading cause of death in the United States was stroke. Worldwide, in 2013, stroke was the second leading cause of death behind ischemic heart disease. Stroke is also a leading cause of disability. This entry examines the epidemiology of stroke, primarily in the US, with emphasis on persons 65 years of age and older and blacks.