Multiple sclerosis sibling pairs: Clustered onset and familial predisposition

Academic Article


  • We evaluated 48 relapsing-remitting multiple sclerosis (R/R MS) sibling pairs derived from 44 families for age and date of onset of MS symptoms, clinical course, and family history of MS. Age- and sex-matched R/R MS clinic patients provided a statistical comparison group. The age of onset tended to cluster within multiplex families. The initial symptom of MS occurred within 5 years of age in 30/48 sibling pairs compared with 16/48 controls. A positive family history of MS (other than siblings) was present in 43% of the multiplex families compared with 20% among simplex controls. In 1st-, 2nd-, and 3rd-degree relatives who had lived into the age at risk, 22/1,134 family members of multiplex sibling pairs had probable or definite MS compared with 10/1,215 control family members. Age of onset clustering in siblings concordant for R/R MS and an increased risk of MS in other family members suggest that factors influencing disease onset may be in part inherited in these kindreds. © 1990 American Academy of Neurology.
  • Published In

  • Neurology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Doolittle TH; Myers RH; Lehrich JR; Birnbaum G; Sheremata W; Franklin GM; Nelson LM; Hauser SL
  • Start Page

  • 1546
  • End Page

  • 1552
  • Volume

  • 40
  • Issue

  • 10