Morphometric analysis of the prefrontal cortex in huntington’s disease

Academic Article


  • We performed a morphometric analysis of cresyl violet-stained sections from the dorsolateral prefrontal cortex of 81 patients with Huntington’s disease (HD) (grades 2, 3, and 4) and 23 age-matched normal controls. We counted large pyramidal neurons, small neurons, astrocytes, oligodendroglia, and microglia under the guidance of a specifically predefined set of morphologic criteria for each cell type and recorded the thickness of each cortical layer. Our results demonstrate a selective and progressive loss of a subset of the large pyramidal neurons in cortical layers III, V, and VI of HD patients, and a decrease in the thickness of the respective cortical laminae. A genetically determined, cell-autonomous degeneration of cortical neurons could constitute the primary pathologic process. However, the loss of only a fraction of pyramidal cells suggests a parallel, or an alternative, possibility of a retrograde degeneration of cortical neurons that project solely, or principally, to the site of primary degeneration in caudate nuclei. © 1991 American Academy of Neurology.
  • Published In

  • Neurology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Sotrel A; Paskevich PA; Kiely DK; Bird ED; Williams RS; Myers RH
  • Start Page

  • 1117
  • End Page

  • 1123
  • Volume

  • 41
  • Issue

  • 7