Potential impact of a predictive test on the gene frequency of Huntington disease

Academic Article


  • Fifty-five individuals at 50% risk of inheriting Huntington disease (HD) were given in-depth structured inverviews to survey attitudes toward use of a predictive test and to assess the possible impact of such at test on the number of gene carriers born. Three-quarters of the sample said they would take predictive test. Given a positive predictive or prenatal test, the number of individuals choosing to have children is reduced from 80% of the total sample to 42%, or by almost one-half. The large proportion of at risk individuals who say they would use a predictive test underscores the importance of developing guidelines for its administration prior to implementation.
  • Digital Object Identifier (doi)

    Author List

  • Schoenfeld M; Myers RH; Berkman B; Clark E
  • Start Page

  • 423
  • End Page

  • 429
  • Volume

  • 18
  • Issue

  • 3