Enantiospecific formation of 3,6-dihydro-1H-pyridin-2-ones: Low-pressure palladium-catalysed decarboxylative carbonylation of 3-tosyl-5-vinyloxazolidin- 2-ones

Academic Article


  • Palladium-catalysed decarboxylative carbonylation of 3-tosyl-5- vinyloxazolidin-2-ones 5 occurs at atmospheric pressure to give 1-tosyl-3,6-dihydro-1H-pyridin-2-ones 6. The reaction proceeds with no loss of enantiopurity and detosylation with sodium naphthalenide gives the title compounds in good yields. © Georg Thieme Verlag Stuttgart.
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    Author List

  • Knight JG; Lawson IM; Johnson CN
  • Start Page

  • 227
  • End Page

  • 230
  • Issue

  • 2