Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-κB activation

Academic Article


  • CARMA1 is a central regulator of NF-κB activation in lymphocytes. CARMA1 and Bcl10 functionally interact and control NF-κB signaling downstream of the T-cell receptor (TCR). Computational analysis of expression neighborhoods of CARMA1-Bcl10MALT 1 for enrichment in kinases identified calmodulin-dependent protein kinase II (CaMKII) as an important component of this pathway. Here we report that Ca /CaMKII is redistributed to the immune synapse following T-cell activation and that CaMKII is critical for NF-κB activation induced by TCR stimulation. Furthermore, CaMKII enhances CARMA1-induced NF-κB activation. Moreover, we have shown that CaMKII phosphorylates CARMA1 on Ser109 and that the phosphorylation facilitates the interaction between CARMA1 and Bcl10. These results provide a novel function for CaMKII in TCR signaling and CARMA1-induced NF-κB activation. Copyright © 2006, American Society for Microbiology. All Rights Reserved. 2+
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    Author List

  • Ishiguro K; Green T; Rapley J; Wachtel H; Giallourakis C; Landry A; Cao Z; Lu N; Takafumi A; Goto H
  • Start Page

  • 5497
  • End Page

  • 5508
  • Volume

  • 26
  • Issue

  • 14