Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Academic Article

Abstract

  • By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P 5 × 10 8. These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits. © 2010 Nature America, Inc. All rights reserved.
  • Authors

    Published In

  • Nature Genetics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Voight BF; Scott LJ; Steinthorsdottir V; Morris AP; Dina C; Welch RP; Zeggini E; Huth C; Aulchenko YS; Thorleifsson G
  • Start Page

  • 579
  • End Page

  • 589
  • Volume

  • 42
  • Issue

  • 7