Mitochondrial involvement in psychiatric disorders

Academic Article

Abstract

  • Recent findings of mitochondrial abnormalities in brains from subjects with neurological disorders have led to a renewed search for mitochondrial abnormalities in psychiatric disorders. A growing body of evidence suggests that there is mitochondrial dysfunction in schizophrenia, bipolar disorder, and major depressive disorder, including evidence from electron microscopy, imaging, gene expression, genotyping, and sequencing studies. Specific evidence of dysfunction such as increased common deletion and decreased gene expression in mitochondria in psychiatric illnesses suggests that direct examination of mitochondrial DNA from postmortem brain cells may provide further details of mitochondrial alterations in psychiatric disorders. © 2008 Informa UK Ltd. (Informa Healthcare, Taylor & Francis AS).
  • Published In

  • Annals of Medicine  Journal
  • Digital Object Identifier (doi)

    Author List

  • Shao L; Martin MV; Watson SJ; Schatzberg A; Akil H; Myers RM; Jones EG; Bunney WE; Vawter MP
  • Start Page

  • 281
  • End Page

  • 295
  • Volume

  • 40
  • Issue

  • 4