Durability of treatment with methotrexate in Venezuelan patients with rheumatoid arthritis

Academic Article


  • A multicenter, national, retrospective, and cross-sectional study of 219 hospital-based Venezuelan patients with rheumatoid arthritis (RA) was aimed to evaluate the probability of continuity of treatment with oral methotrexate (MTX). Treatment survival decreased from 92% at 12 months to 42% at 180 months, as assessed by life table analysis and the Kaplan-Meier method. Forty-seven patients stopped treatment and adverse effects (29.7%) and lack of continuous access to medication (19.1%) were the most common causes for withdrawal. MTX survival was decreased in the group with combined MTX plus leflunomide therapy, as shown by the log-rank test. Venezuelan patients with RA have a probability of continuing treatment with oral MTX comparable to non-Hispanic patient populations. However, concomitant use of leflunomide may increase the risk of interruption of MTX treatment in this RA population. © 2006 Springer-Verlag.
  • Digital Object Identifier (doi)

    Author List

  • Sánchez G; Castro JS; Snih SA; Blanco LP; Esteva MH; MacGregor EG; González M; Granados Y; Marín F; Rosas A
  • Start Page

  • 531
  • End Page

  • 536
  • Volume

  • 27
  • Issue

  • 6