Human IFN-γ up-regulates IL-2 receptors in mitogen-activated T lymphocytes

Academic Article

Abstract

  • This study examined the role of human recombinant interferon-gamma (rIFN-γ) in the expression of interleukin-2 receptors (IL-2R) by human T lymphocytes. rIFN-γ enhanced total numbers of IL-2R in mitogen-activated but not resting T cells. Scatchard plot analysis indicated that rIFN-γ increased both high- and low-affinity receptors, with a predominant effect on the latter. Phytohaemagglutinin (PHA)-activated T cells treated with IFN-γ showed higher IL-2 binding and greater IL-2 internalization and degradation than cells treated with PHA alone. There was a corresponding increase of mitogen-driven proliferative responses, indicating an increase of functional receptors in IFN-treated cultures. IFN-γ may influence T-cell activation and proliferation by enhancing expression of IL-2R and promoting IL-2 uptake by mitogen-activated lymphocytes.
  • Published In

  • Immunology  Journal
  • Author List

  • Rodriguez MA; De Sanctis JB; Blasini AM; Leon-Ponte M; Abadi I
  • Start Page

  • 554
  • End Page

  • 557
  • Volume

  • 69
  • Issue

  • 4