Human alpha‐interferon enhances in vitro igm rheumatoid factor synthesis by lymphocytes from normal subjects and rheumatoid arthritis patients

Academic Article


  • Alpha‐interferon (α‐IFN) was added to pokeweed mitogen (PWM) or Epstein‐Barr virus stimulated human peripheral blood mononuclear cell cultures from normal subjects or patients with rheumatoid arthritis (RA). Alpha‐IFN enhanced in vitro production of PWM induced IgG and IgM, and significantly enhanced PWM induced IgM rheumatoid factor (IgM‐RF) production by lymphocytes both from normal subjects and RA patients. Enhancement was recorded whether cells were preincubated with α‐IFN for 16 hours or with α‐IFN present throughout the culture period. Alpha‐IFN did not enhance IgM‐RF production in the absence of PWM or T cells. Enhancement of IgM‐RF production was not seen in Epstein‐Barr virus stimulated cultures. Copyright © 1983 American College of Rheumatology
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    Digital Object Identifier (doi)

    Author List

  • Rodriguez MA; Prinz WA; Sibbitt WL; Bankhurst AD; Williams RC
  • Start Page

  • 1091
  • End Page

  • 1097
  • Volume

  • 26
  • Issue

  • 9