Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats

Academic Article


  • This study was designed to test the effects of angiotensin-converting enzyme (ACE) inhibition on body composition and physical performance in aged rats. Male Brown Norway × F344 rats were randomized to receive daily injections of enalapril (40 mg/kg or 80 mg/kg) or saline from 24 to 30 months of age. Body composition was determined using dual-energy X-ray absorptiometry (DXA), and physical performance was assessed using the grip strength and inclined plane procedures. Performance measures were assessed at baseline and monthly thereafter. DXA was performed at baseline, 3 months, and 6 months of follow-up. Compared with the enalapril groups, the saline group experienced a greater 6-month decline in the physical performance measures. Lean body mass declined in both groups; however, the enalapril groups also experienced a significant loss of fat mass. These results suggest that ACE inhibition may prevent age-related declines in physical performance, which may be mediated by a reduction in body fat mass.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Carter CS; Cesari M; Ambrosius WT; Hu N; Diz D; Oden S; Sonntag WE; Pahor M
  • Start Page

  • 416
  • End Page

  • 423
  • Volume

  • 59
  • Issue

  • 5