© The Author(s) 2018. Published by Oxford University Press. All rights reserved. This article has been updated to include the following text in the Acknowledgements section: The Framingham Heart Study is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with Boston University (Contract No.N01-HC-25195 and HHSN268201500001I). This manuscriptwas not prepared in collaboration with investigators of the Framingham Heart Study and does not necessarily reflect the opinions or views of the Framingham Heart Study, Boston University, or NHLBI. Additional funding for SABRe was provided by Division of Intramural Research, NHLBI, and Center for opulation Studies, NHLBI.