The Amino-Terminal Sequence of the Heavy Chain of Human Immunoglobulin M

Academic Article


  • In the study of the heavy chain from four IgM immunoglobulins no α-amino-terminal group was detected by fluorodinitrobenzene, cyanate, or dimethylaminonaphthalenesulfonyl chloride. The N-terminal residue appears to be a pyrrolidonecarboxylic acid in all four cases. The N-terminal peptide from each of the four has been isolated and a partial sequence determination carried out. The sequences extending over five to nine residues reveal a structural homology among these μ chains and suggest homology with other immunoglobulin chains. © 1968, American Chemical Society. All rights reserved.
  • Authors

    Published In

  • Biochemistry  Journal
  • Digital Object Identifier (doi)

    Author List

  • Bennett JC
  • Start Page

  • 3340
  • End Page

  • 3344
  • Volume

  • 7
  • Issue

  • 10