Cancer risk in Lynch Syndrome

Academic Article


  • Lynch Syndrome, or hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by inactivating mutations in DNA mismatch repair genes. It accounts for 2-4 % of all incident colorectal cancers. Mutation carriers are at risk of early onset colorectal cancer, endometrial cancer, and a spectrum of other tumours. Accurate estimation of cancer risk for mutation carriers is essential for counselling, and establishing appropriate screening guidelines. This study reviews the current data on cancer risk, and emerging risk reduction strategies. © 2013 Springer Science+Business Media Dordrecht.
  • Authors

    Published In

  • Familial Cancer  Journal
  • Digital Object Identifier (doi)

    Author List

  • Barrow E; Hill J; Gareth Evans D
  • Start Page

  • 229
  • End Page

  • 240
  • Volume

  • 12
  • Issue

  • 2