BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

Academic Article


  • Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age. Copyright © 2005 by AAN Enterprises, Inc.
  • Published In

  • Neurology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Karamohamed S; Latourelle JC; Racette BA; Perlmutter JS; Wooten GF; Lew M; Klein C; Shill H; Golbe LI; Mark MH
  • Start Page

  • 1823
  • End Page

  • 1825
  • Volume

  • 65
  • Issue

  • 11