Long-Term Survival After Transformation of an Adrenocorticotropic Hormone–Secreting Pituitary Macroadenoma to a Silent Corticotroph Pituitary Carcinoma

Academic Article


  • Background: Pituitary carcinomas are rare and aggressive neoplasms that despite current treatment regimens continue to have a poor prognosis. Adrenocorticotrophic hormone pituitary tumors have been shown to alter their clinical manifestations with conversion to Cushing disease and silent types. Case Description: The purpose of this paper is to present the first documented case of an adrenocorticotrophic hormone–secreting pituitary adenoma with Cushing disease that differentiated into a silent corticotroph pituitary carcinoma with metastases to distant sites in the central nervous system. Conclusions: This patient was later treated with radiotherapy, temozolomide, and bevacizumab, with 8 years of progression-free survival.
  • Published In

  • World Neurosurgery  Journal
  • Digital Object Identifier (doi)

    Author List

  • Rotman LE; Vaughan TB; Hackney JR; Riley KO
  • Start Page

  • 417
  • End Page

  • 423
  • Volume

  • 122