Hemodynamic effects of nifedipine in normoxic and hypoxic newborn lambs

Academic Article


  • We studied the effects of nifedipine, a calcium-channel blocker, in 2 acutely instrumented groups of newborn lambs during normoxic and hypoxic conditions. Nifedipine at 10 or more μg/kg reduced systemic, but not pulmonary artery pressure and resistance in normoxic lambs. When acute hypoxia was produced in these animals, 50 or more μg/kg reduced, but did not prevent, the expected rise in pulmonary pressure and resistance. When infused into already hypoxic lambs, nifedipine in doses of 50 μg/kg or more reduced both systemic and pulmonary pressures and resistances equally. Thus, nifedipine is a nonspecific vasodilator in newborn lambs.
  • Author List

  • Philips JB; Lyrene RK; Leslie GI; McDevitt M; Cassady G
  • Start Page

  • 23
  • End Page

  • 30
  • Volume

  • 5
  • Issue

  • 1