Prior research has estimated the impact of an autonomous vehicle (AV) environment on the mobility of underserved populations such as adult non-drivers. What is currently unknown is the impact of AVs on enhancing the mobility of children who are also mobility disadvantaged, as child passengers are likely part of AV ridership scenarios in the perceivable future. To address this question, our study collected perceived benefits and concerns of AVs from a US convenience sample of parents whose children relied on them for mobility. We found that parents’ intentions to travel in AV and their technology readiness as well as parent (sex, residence area) and child (age, restraint system) demographic profiles were important determinants of potential AV acceptance and impact. In addition, two groups of potential AV users emerged from the data: the curious and the practical. This study addresses a gap in the literature by assessing parents’ perspectives on using AVs to transport children. The results have great potentials to guide the design of mobility features, safety evaluations, and implementation policies, as a decline in public interest in AVs has been recently documented.