Effect of nifedipine in hypothermic cardioplegia: a phosphorus-31 nuclear magnetic resonance study

Academic Article

Abstract

  • The ability of nifedipine to enhance myocardial protection was assessed on isolated perfused rat hearts subjected to 180 min of hypothermic (20°C), global ischemia, followed by 45 min of normothermic reperfusion. Intracellular pH, ATP, pi and phosphocreatine content were serially measured at 4 min intervals by phosphorus-31 nuclear magnetic resonance spectroscopy and correlated with simultaneously recorded hemodynamic parameters. Addition of nifedipine (0.075 μmol/l and 0.5 μmol/l) to Saint Thomas' cardioplegic solution reduced Pi accumulation during ischemic arrest and increased phosphocreatine levels during reperfusion. Post-ischemic functional recovery was not improved at a drug concentration of 0.075 μmol/l and was depressed at 0.5 μmol/l. These results clearly show that the presence of nifedipine in Saint Thomas' cardioplegic solution does not provide significant additional myocardial protection under hypothermic conditions. © 1985.
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    Digital Object Identifier (doi)

    Author List

  • Bernard M; Menasché P; Fontanarava E; Canioni P; Grousset C; Piwnica A; Cozzone P
  • Start Page

  • 43
  • End Page

  • 53
  • Volume

  • 152
  • Issue

  • 1-2