Myoblast transplantation for heart failure

Academic Article


  • Intramyocardial skeletal muscle transplantation has been shown experimentally to improve heart function after infarction. We report success with this procedure in a patient with severe ischaemic heart failure. We implanted autologous skeletal myoblasts into the postinfarction scar during coronary artery bypass grafting of remote myocardial areas. 5 months later, there was evidence of contraction and viability in the grafted scar on echocardiography and positron emission tomography. Although this result is encouraging, it requires validation by additional studies.
  • Digital Object Identifier (doi)

    Author List

  • MenaschĂ© P; Hagège AA; Scorsin M; Pouzet B; Desnos M; Duboc D; Schwartz K; Vilquin JT; Marolleau JP
  • Start Page

  • 279
  • End Page

  • 280
  • Volume

  • 357
  • Issue

  • 9252