MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-Mesenchymal transition (EMT) phenotype and are highly invasive in Vitro

Academic Article

Abstract

  • Background: LOXL2 induces metastasis/invasion of breast cancer cells. Results: MCF-7 cells expressing nuclear associated LOXL2 have an invasive EMT phenotype. Conclusion: Nuclear associated catalytically competent LOXL2 contributes to stabilization of Snail1 transcription factor. Significance: This is the first study to directly compare the potencies of nuclear associated and secreted LOXL2s in breast cancer metastasis/invasion in vitro. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 9907874
  • Author List

  • Moon HJ; Finney J; Xu L; Moore D; Welch DR; Mure M
  • Start Page

  • 30000
  • End Page

  • 30008
  • Volume

  • 288
  • Issue

  • 42