Background: LOXL2 induces metastasis/invasion of breast cancer cells. Results: MCF-7 cells expressing nuclear associated LOXL2 have an invasive EMT phenotype. Conclusion: Nuclear associated catalytically competent LOXL2 contributes to stabilization of Snail1 transcription factor. Significance: This is the first study to directly compare the potencies of nuclear associated and secreted LOXL2s in breast cancer metastasis/invasion in vitro. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.