APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies.

Academic Article


  • INTRODUCTION: Although the apolipoprotein E ε4-allele (APOE-ε4) is a susceptibility factor for Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), its relationship with imaging and cognitive measures across the AD/DLB spectrum remains unexplored. METHODS: We studied 298 patients (AD = 250, DLB = 48; 38 autopsy-confirmed; NCT01800214) using neuropsychological testing, volumetric magnetic resonance imaging, and APOE genotyping to investigate the association of APOE-ε4 with hippocampal volume and learning/memory phenotypes, irrespective of diagnosis. RESULTS: Across the AD/DLB spectrum: (1) hippocampal volumes were smaller with increasing APOE-ε4 dosage (no genotype × diagnosis interaction observed), (2) learning performance as assessed by total recall scores was associated with hippocampal volumes only among APOE-ε4 carriers, and (3) APOE-ε4 carriers performed worse on long-delay free word recall. DISCUSSION: These findings provide evidence that APOE-ε4 is linked to hippocampal atrophy and learning/memory phenotypes across the AD/DLB spectrum, which could be useful as biomarkers of disease progression in therapeutic trials of mixed disease.
  • Authors

    Published In


  • APOE, Alzheimer's disease, Dementia with Lewy bodies, Endophenotype, Hippocampus, Learning, MRI, Memory, Aged, Alzheimer Disease, Apolipoprotein E4, Endophenotypes, Female, Genetic Predisposition to Disease, Heterozygote, Hippocampus, Humans, Learning, Lewy Body Disease, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Organ Size
  • Digital Object Identifier (doi)

    Pubmed Id

  • 8900705
  • Author List

  • Saeed U; Mirza SS; MacIntosh BJ; Herrmann N; Keith J; Ramirez J; Nestor SM; Yu Q; Knight J; Swardfager W
  • Start Page

  • 1137
  • End Page

  • 1147
  • Volume

  • 14
  • Issue

  • 9