New substrate analogues as inhibitors of s-adenosylmethionine decarboxylase


  • Analogues of S-adenosylmethionine with modifications in the 5'group were prepared as potential inhibitors of S-adenosylmethionine decarboxylase (AdoMet-DC). These new analogues contained carbonyl-reactive end groups in the 5'side chain, designed to interact favorably with the pyruvate prosthetic group of AdoMet-DC. Several of the analogues proved to be outstanding inhibitors of the enzyme. The analogues were also evaluated for their activity against human cytomegalovirus in vitro. © 1987, Taylor & Francis Group, LLC. All rights reserved.
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  • 73
  • End Page

  • 83
  • Volume

  • 6