Preparation of 1,4-disubstituted-1,2,3-triazolo ribonucleosides by Na 2CuP2O7 catalyzed azide-alkyne 1,3-dipolar cycloaddition

Academic Article

Abstract

  • In this study, we describe the synthesis of 1,4-disustituted-1,2,3- triazolo-ribonucleosides by means of 1,3-dipolar cycloaddition between various N-1 propargyl-pyrimidines and 1'-azido-2',3',5'-tri-O-benzoylribose catalyzed by Na2CuP2O7/sodium ascorbate. All obtained compounds were evaluated for their anti-HCV activity in vitro. © ARKAT-USA, Inc.
  • Digital Object Identifier (doi)

    Author List

  • Elayadi H; Mesnaoui M; Korba BE; Smietana M; Vasseur JJ; Secrist JA; Lazrek HB
  • Start Page

  • 76
  • End Page

  • 89
  • Volume

  • 2012
  • Issue

  • 8