Efficient Syntheses of the Marine Alkaloiss Makaluvamine D and Discorhabdnn C: The 4,6,7-Trimethoxyindole Approach

Academic Article

Abstract

  • A new and efficient synthesis of the tricyclic quinonimine 20 as its trifluoroacetate 23 has been developed starting from the commercially available 2,4,5-trimethoxybenzaldehyde and proceeding via the hitherto unknown 4,6,7-trimethoxyindole (7). Quinonimine 23 is the late stage key intermediate in several previously reported syntheses of the biologically active pyrrolo[4,3,2-del-quinoline marine alkaloids discorhabdin C (1) and makaluvamine D (3). © 1995, American Chemical Society. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 15364293
  • Author List

  • Sadanandan EV; Pillai SK; Lakshmikantham MV; Billimoria AD; Culpepper JS; Cava MP
  • Start Page

  • 1800
  • End Page

  • 1805
  • Volume

  • 60
  • Issue

  • 6