SRI-286, a thiosemicarbazole, in combination with mefloquine and moxifloxacin for treatment of murine Mycobacterium avium complex disease

Academic Article


  • Treatment of Mycobacterium avium disease remains challenging when macrolide resistance develops. We infected C57 beige mice and treated them with mefloquine, SRI-286, and moxifloxacin. SRI-286 (80 mg/kg) was bactericidal in the liver. Mefloquine plus moxifloxacin or mefloquine plus SRI-286 were better than mefloquine alone.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 15607657
  • Author List

  • Bermudez LE; Kolonoski P; Seitz LE; Petrofsky M; Reynolds R; Wu M; Young LS
  • Start Page

  • 3556
  • End Page

  • 3558
  • Volume

  • 48
  • Issue

  • 9