The presynaptic active zone protein RIM1α is critical for normal learning and memory

Academic Article


  • The active zone protein RIM1α is required both for maintaining normal probability of neurotransmitter release and for long-term presynaptic potentiation at brain synapses. We now demonstrate that RIM1α -/- mice exhibit normal coordination and anxiety-related behaviors but display severely impaired learning and memory. Mice with a synaptotagmin 1 mutation, which selectively lowers release probability, and mice with Rab3A deletion, which selectively abolishes presynaptic long-term potentiation, do not exhibit this abnormality. Our data suggest that a decrease in release probability or a loss of presynaptic LTP alone is not sufficient to cause major behavioral alterations, but the combination of presynaptic abnormalities in RIM1α-/- mice severely alters learning and memory.
  • Authors

    Published In

  • Neuron  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 25290039
  • Author List

  • Powell CM; Schoch S; Monteggia L; Barrot M; Matos MF; Feldmann N; Südhof TC; Nestler EJ
  • Start Page

  • 143
  • End Page

  • 153
  • Volume

  • 42
  • Issue

  • 1