Lowering β-amyloid levels rescues learning and memory in a down syndrome mouse model

Academic Article


  • β-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if β-amyloid contributes to intellectual disability in younger individuals. We used a γ-secretase inhibitor to lower β-amyloid levels in young mice that model DS. This treatment corrected learning deficits characteristic of these mice, suggesting that β-amyloid-lowering therapies might improve cognitive function in young DS patients. © 2010 Netzer et al.
  • Authors

    Published In

  • PLoS One  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 25403020
  • Author List

  • Netzer WJ; Powell C; Nong Y; Blundell J; Wong L; Duff K; Flajolet M; Greengard P
  • Volume

  • 5
  • Issue

  • 6