In vitro and in vivo effects of quinidine on the kidneys in Fischer-344 rats

Academic Article

Abstract

  • Quinidine in vitro significantly reduced accumulation of TEA (tetraethyl ammonium) and PAH (p-amino hippurate) and inhibited oxygen consumption in renal cortical slices. Mitochondrial respiratory control index (RCI) and ADP/O ratio were decreased. Intraperitoneal administration of quinidine at 75 mg/kg twice a day for four days inhibited TEA transport in renal cortical slices and decreased oxygen consumption. Mitochondria showed a reduction in ADP/O ratio but no change in RCI. Serum biochemical measurements indicated a significant elevation in serum creatinine, alanine aminotransferase (ALT), and aspartate aminotransferase (AST).
  • Author List

  • Agarwal AK; Rao SS
  • Start Page

  • 143
  • End Page

  • 150
  • Volume

  • 82
  • Issue

  • 2