Evaluation of nicotine and cotinine analogs as potential neuroprotective agents for Alzheimer's disease.

Academic Article

Abstract

  • The currently available therapies for Alzheimer's disease (AD) and related forms of dementia are limited by modest efficacy, adverse side effects, and the fact that they do not prevent the relentless progression of the illness. The purpose of the studies described here was to investigate the neuroprotective effects of the nicotine metabolite cotinine as well as a small series of cotinine and nicotine analogs (including stereoisomers) and to compare their effects to the four clinically prescribed AD therapies.
  • Authors

    Keywords

  • Amyloid, Dementia, Disease modifying, Excitotoxicity, Glutamate, Multi-target-directed ligands, Multifunctional compounds, Neurodegeneration, Neuroprotection, Nicotinic, Alzheimer Disease, Amyloid beta-Peptides, Animals, Cell Survival, Cells, Cultured, Cotinine, Humans, Neurons, Neuroprotective Agents, Nicotine, Peptide Fragments, Rats, Receptors, N-Methyl-D-Aspartate
  • Digital Object Identifier (doi)

    Author List

  • Gao J; Adam B-L; Terry AV
  • Start Page

  • 1472
  • End Page

  • 1478
  • Volume

  • 24
  • Issue

  • 6