Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

Academic Article

Abstract

  • © 2014 Nature America, Inc. All rights reserved. Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10 '21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10 '10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10 '8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10 '13 and 3.63 × 10 '11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
  • Authors

    Published In

  • Nature Genetics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Cerhan JR; Berndt SI; Vijai J; Ghesquières H; McKay J; Wang SS; Wang Z; Yeager M; Conde L; De Bakker PIW
  • Start Page

  • 1233
  • End Page

  • 1238
  • Volume

  • 46
  • Issue

  • 11