Background: There is growing interest in computer-delivered psychological interventions for a number of clinical conditions, including pain. Objectives: This study tests the effectiveness of a new computer-delivered pain-management program using a laboratory pain paradigm. Methods: One hundred twenty undergraduate students were randomly assigned to either the computerized pain-management group or the distraction control group. Subjects underwent a cold-pressor task and were asked to continuously rate their subjective pain experience. Results: Women receiving the computerized pain management intervention were able to tolerate the cold-pressor task longer than those in the control group. No effect was found for men. Subjective pain ratings were consistently lower during the cold-pressor task for subjects in the computerized pain-management group regardless of sex. Subjects receiving the computerized intervention reported feeling more comfortable and relaxed than control subjects during the cold-pressor task. Conclusions: Findings indicate that further investigations of the program used in this study are warranted to determine its potential clinical utility and that of similar computerized interventions for pain. © 2004 Pulsus Group Inc. All rights reserved.