Ten-year outcome of patients with acute myeloid leukemia not treated with allogeneic transplantation in first complete remission

Academic Article

Abstract

  • The probability that adult patients with de novo acute myeloid leukemia (AML) receiving intensive chemotherapy in the absence of allogeneic hematopoietic stem cell transplantation (Allo-HCT) in first complete remission (CR1) will be disease-free at 10 years after diagnosis, a long-term surrogate of cure, is unknown. To address this question, we examined 2551 AML patients (1607 aged,60 years, and 944 aged $60 years) enrolled in Cancer and Leukemia Group B treatment protocols and the cytogenetics companion protocol 8461 between 1983 and 2004. At 10 years, 267 (16.6%) of patients aged,60 years and 23 (2.4%) of those aged $60 years were alive and disease-free. This disease-free AML group consisted predominantly of patients with core-binding factor AML with t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22) and those with a normal karyotype. Occurrences of AML beyond 10 years were infrequent and associated with cytogenetic findings different from those at diagnosis. These data provide evidence that the frequency of long-term cure of AML is low among younger and especially older patients in the absence of Allo-HCT in CR1. In older patients not appropriate for Allo-HCT, these data provide further justification for early use of alternative treatments outside of intensive chemotherapy.
  • Published In

  • Blood Advances  Journal
  • Digital Object Identifier (doi)

    Author List

  • Vasu S; Kohlschmidt J; Mr√≥zek K; Eisfeld AK; Nicolet D; Sterling LJ; Becker H; Metzeler KH; Papaioannou D; Powell BL
  • Start Page

  • 1645
  • End Page

  • 1650
  • Volume

  • 2
  • Issue

  • 13