Post-translational modifications of Runx1 regulate its activity in the cell

Academic Article

Abstract

  • In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy. © 2009 Elsevier Inc. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Wang L; Huang G; Zhao X; Hatlen MA; Vu L; Liu F; Nimer SD
  • Start Page

  • 30
  • End Page

  • 34
  • Volume

  • 43
  • Issue

  • 1