Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis

Academic Article

Abstract

  • Purpose: Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies. Methods: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis. Results: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d. Conclusion: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation. © 2013 Wichtig Editore.
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    Digital Object Identifier (doi)

    Author List

  • Roy-Chaudhury P; Khan R; Campos B; Wang Y; Kurian M; Lee T; Arend L; Munda R
  • Start Page

  • 25
  • End Page

  • 28
  • Volume

  • 15
  • Issue

  • 1