Obstructive sleep apnea (OSA) is a chronic condition characterized by occlusion of the upper airway during sleep resulting in daytime sleepiness. Drivers with OSA are at a two- to sevenfold increase in risk of motor vehicle crashes (MVCs). Approximately, 13% to 28% of commercial motor vehicle drivers (CMVDs) are thought to have OSA. Obstructive sleep apnea is a significant issue in the transportation industry. Currently, The Federal Motor Carrier Safety Association (FMCSA) does not mandate OSA screening. Federal regulations only specify that CMVDs be free of “respiratory dysfunction” that would impair driving. Untreated OSA is a public safety concern. The purpose of this article is to use Bardach’s eightfold policy analysis approach to examine policy options related to OSA screening in the trucking industry.