Roles of STATs signaling in cardiovascular diseases.

Academic Article

Abstract

  • In cardiac and many other systems, chronic stress activates avfamily of structurally and functionally conserved receptors and their downstream signaling molecules that entail tyrosine, serine or threonine phosphorylation to transfer the messages to the genetic machinery. However, the activation of the Janus kinases (JAKs) and their downstream signal transducer and activator of transcription (STATs) proteins is both characteristic of and unique to cytokine and growth factor signaling which plays a central role in heart physiology. Dysregulation of JAK-STAT signaling is associated with various cardiovascular diseases. The molecular signaling and specificity of the JAK-STAT pathway are modulated at many levels by distinct regulatory proteins. Here, we review recent studies on the regulation of the STAT signaling pathway that will enhance our ability to design rational therapeutic strategies for stress-induced heart failure.
  • Authors

    Published In

  • JAK-STAT  Journal
  • Keywords

  • JAK-STAT signaling, cardio-protection, heart, heart failure, inflammation
  • Digital Object Identifier (doi)

    Author List

  • Kishore R; Verma SK
  • Start Page

  • 118
  • End Page

  • 124
  • Volume

  • 1
  • Issue

  • 2