Conditioned Insulin Secretion in the Albino Rat

Academic Article


  • Although the phenomenon of conditioned hypoglycemia is now well established, little is known about its mechanism. The present experiments lead to the conclusion that the mechanism involves a release of insulin: Experiment 1 showed that rats given an injection of streptozotocin, a drug which destroys the beta cells of the islets of Langerhans, did not show a conditioned hypoglycemia, whereas rats given only the vehicle for the streptozotocin did; and in experiment 2, blood drawn from conditioned rats just before the conditioned hypoglycemia would normally occur showed greater insulinlike activity than blood drawn from control rats. These results demonstrate a conditioned release of some hypoglycemic agent that depends upon the integrity of the beta cells. A neural control over release of insulin must be inferred to explain them. © 1970, SAGE Publications. All rights reserved.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Woods SC; Hutton RA; Makous W
  • Start Page

  • 964
  • End Page

  • 968
  • Volume

  • 133
  • Issue

  • 3