The disease-focused panel (DFP) program was created by the Society of Abdominal Radiology (SAR) as a mechanism to “improve patient care, education, and research” in a “particular disease or a particular aspect of a disease”. The DFP on renal cell carcinoma (RCC) was proposed in 2014 and has been functional for 4 years. Although nominally focused on RCC, the scope of the DFP has included indeterminate renal masses because many cannot be assigned a specific diagnosis when detected. Since its founding, the DFP has been active in a variety of clinical, research, and educational projects to optimize the care of patients with known or suspected RCC. The DFP is utilizing multi-institutional and cross-disciplinary collaboration to differentiate benign from malignant disease, optimize the management of early stage RCC, and ultimately to differentiate indolent from aggressive cancers. Several additional projects have worked to develop a quantitative biomarker that predicts metastatic RCC response to anti-angiogenic therapy. While disease focus is the premise by which all DFPs are created, it is likely that in the future the RCC DFP will need to expand or create new panels that will focus on other specific aspects of RCC—a result that the program’s founders envisioned. New knowledge creates a need for more focus.