A kiss of death - Proteasome-mediated membrane fusion and programmed cell death in plant defense against bacterial infection

Academic Article


  • Eukaryotes have evolved various means for controlled and organized cellular destruction, known as programmed cell death (PCD). In plants, PCD is a crucial regulatory mechanism in multiple physiological processes, including terminal differentiation, senescence, and disease resistance. In this issue of Genes & Development, Hatsugai and colleagues (pp. 2496-2506) demonstrate a novel plant defense strategy to trigger bacteria-induced PCD, involving proteasome-dependent tonoplast and plasma membrane fusion followed by discharge of vacuolar antimicrobial and death-inducing contents into the apoplast. © 2009 by Cold Spring Harbor Laboratory Press.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Pajerowska-Mukhtar K; Dong X
  • Start Page

  • 2449
  • End Page

  • 2454
  • Volume

  • 23
  • Issue

  • 21