Bullous pemphygoid is an uncommon cause of atypical esophagitis. Nevertheless, awareness of this condition is important to make a diagnosis and institute appropriate therapy. There are many autoimmune skin disorders that also affect the esophagus, as both skin and esophagus are covered with squamous epithelium. Some of these blister- and bullae-forming diseases are bullous pemphygoid, pemphygus vulgaris, cicatricial pemphygoid, epidermolysis bullosa acqusita, and lichen planus pemphygoides. Herein is presented a patient with bullous pemphygoid, focusing on the endoscopic and histological characteristics of the disease. This article is part of an expert video encyclopedia. © 2013 Elsevier GmbH.