Effects of active immunization with a pneumococcal surface protein (PspA) and of locally applied antibodies in experimental otitis media

Academic Article


  • An experimental rat model for Streptococcus pneumoniae otitis media was used to investigate passive protection by anti-type 3 capsular antibodies and effects of immunization with pneumococcal surface protein A (PspA). Anti-type 3 antibodies instilled into the middle ear reduced purulent otitis media as compared to control animals (p = 0.015). Secondly, after immunization with PspA, the right middle ear was inoculated with S. pneumoniae type 6A in a dose calibrated to induce purulent otitis media. There was an anti-PspA antibody response in all rats immunized and a reduction in signs of purulent otitis media as compared to control animals (p = 0.026). Thus, purulent (acute) otitis media can be reduced by local application of antibodies in the middle ear and also by immunization with a non-type-specific pneumococcal protein, PspA.
  • Authors

    Published In

  • ORL  Journal
  • Digital Object Identifier (doi)

    Author List

  • White P; Hermansson A; Svanborg C; Briles D; Prellner K
  • Start Page

  • 206
  • End Page

  • 211
  • Volume

  • 61
  • Issue

  • 4