Comparative in vitro activities of four new fluoroquinolones against Streptococcus pneumoniae determined by Etest

Academic Article


  • Clinafloxacin, levofloxacin, sparfloxacin and trovafloxacin were tested by Etest against 188 Streptococcus pneumoniae isolates. Clinafloxacin and trovafloxacin were 2-4-fold more potent than sparfloxacin and 8-fold more than levofloxacin. Two isolates, both serotype 6, with high-level quinolone resistance (≤ 8 μg/ml) were detected. The Etest is a practical means for determining S. pneumoniae susceptibilities to new fluoruquinolones.
  • Digital Object Identifier (doi)

    Author List

  • Waites K; Brookings E; Nix S; Robinson A; Gray B; Swiatlo E
  • Start Page

  • 215
  • End Page

  • 218
  • Volume

  • 9
  • Issue

  • 4