Tissue culture, protein and collagen synthesis in antibiotic sterilized canine heart valves

Academic Article


  • AUTHORS' SYNOPSIS: Viability of canine heart valve leaflet fibroblasts was assessed after varying periods of sterilization and storage in antibiotic-nutrient solution. Tissue culture and assessment of protein and collagen synthesis showed that tissue obtained undsr optimal conditions rarely retains viability beyond 3 weeks in antibiotic-nutrient solution and is severely impaired after 2 weeks. This casts serious doubts on viability in current clinical homograft valve practice.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 1773190
  • Author List

  • Mcgregor CGA; Bradley JF; Mcgee JOD; Wheatley DJ
  • Start Page

  • 389
  • End Page

  • 393
  • Volume

  • 10
  • Issue

  • 3