Disseminated toxoplasmosis in cardiac transplantation

Academic Article


  • The first case of disseminated toxoplasmosis following cardiac transplantation in the UK is described, with details of Toxoplasma antibody tests made on other cardiac transplant patients. Sixteen of 40 (39%) of recipients had Toxoplasma antibody before operation. Eleven of 30 (37%) of donors had Toxoplasma antibody. There were four occasions when a negative recipient received a heart from a positive donor. Three survived the immediate postoperative period and two became infected with toxoplasmosis. The implications of this are discussed. Disseminated toxoplasmosis appears much more often when heart muscle from a dye test positive donor is fiven to a dye test negative recipient. Antibiotic therapy is limited by the fact that the antitoxoplasma drugs available are static in their effect, and need to be given for prolonged periods postoperatively.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 9131296
  • Author List

  • McGregor CGA; Fleck DG; Nagington J; Stovin PG; Cory-Pearce R; English TA
  • Start Page

  • 74
  • End Page

  • 77
  • Volume

  • 37
  • Issue

  • 1