Secondary organ allografting after a primary “bridging” xenotransplant

Academic Article


  • It remains uncertain whether xenotransplantation can sensitize the recipient to alloantigens, rendering subsequent allotransplantation unsuccessful. This is of considerable importance if a xenograft is to be used as a “bridge” to support the patient until a suitable allograft becomes available. When sera from 9 baboons that had received pig or African green monkey heart or liver xenografts were tested against a panel of lymphocytes from 5 or 6 potential donor baboons, positiv ity was seen in only 1 baboon (and then to only 2 of the potential 5 donors). In 4 baboons that had undergone previous xenotransplants (1 from this series of 9 baboons and 3 others), subsequent organ allografting was not followed by hyperacute, antibody-mediated, or accelerated cellular rejection. We conclude that organ xenotransplantation using discordant or concordant donor species does not prohibit subsequent allo-transplantation. © 1995 by Williams & Wilkins.
  • Authors

    Published In

  • Transplantation  Journal
  • Digital Object Identifier (doi)

    Author List

  • Ye Y; Luo Y; Kobayashi T; Taniguchi S; Li S; Niekrasz M; Kosanke S; Baker J; Mieles L; Smith D
  • Start Page

  • 19
  • End Page

  • 22
  • Volume

  • 60
  • Issue

  • 1